[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
October 1983

Acrokeratosis Paraneoplastica (Bazex' Syndrome): Report of a Case and Review of the Literature

Author Affiliations

From the Department of Internal Medicine, New York Hospital-Memorial Hospital Program (Dr Pecora); and the Departments of Medicine (Drs Landsman and Imgrund) and Pathology/ Dermatopathology (Dr Lambert), the University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark; and the East Orange (NJ) Veterans Administration Medical Center (Drs Landsman and Imgrund).

Arch Dermatol. 1983;119(10):820-826. doi:10.1001/archderm.1983.01650340030015

• Acrokeratosis paraneoplastica (Bazex' syndrome) is a rare but clinically distinctive dermatosis that has been associated in all reported cases, to our knowledge, with either a primary malignant neoplasm of the upper aerodigestive tract or metastatic cancer to the lymph nodes of the neck. Acrokeratosis paraneoplastica was found in a 53-year-old black man with squamous cell carcinoma of the tonsil. A distinctive series of changes was found on histopathologic examination of biopsy specimens taken from his skin lesions, and direct immunofluorescence microscopy of both lesional and nonlesional skin specimens showed immunoglobulin and complement deposition on the epidermal basement membrane. The skin lesions largely resolved following radiation therapy of the neoplasm and of the presumably involved lymph nodes.

(Arch Dermatol 1983;119:820-826)