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November 1983

Treatment of Keratoacanthoma With Topical Fluorouracil

Author Affiliations


From the Dermatology Service, Department of Medicine, Letterman Army Medical Center, Presidio of San Francisco.

Arch Dermatol. 1983;119(11):951-953. doi:10.1001/archderm.1983.01650350079022

My colleagues and I recently described the successful treatment of keratoacanthoma (KA) with intralesional1,2 and topical 20% fluorouracil cream.3 The latter preparation is commercially unavailable and cumbersome to prepare. Therefore, we evaluated the use of topical 5% fluorouracil cream for the treatment of KA, and our results are described herein.

Patients and Methods  Patient data are shown in the Table. Rapidly growing lesions of 4 to 16 mm developed during periods of three to six weeks in 13 patients who ranged in age from 58 to 86 years. One patient had three such lesions when he was examined. All patients met the criteria for the clinical diagnosis of KA, namely, (1) rapid growth of the lesion for two to six weeks, (2) morphologic characteristics of a dome-shaped, smooth, skin-colored or erythematous nodule with a central keratin-filled crater, and (3) subsequent prompt response to topical fluorouracil therapy with at

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