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December 1983

Eruptive Neurofibromatosis Associated With Anorexia Nervosa

Author Affiliations


From the Dermatology Service (Drs Fitzpatrick and May) and Endocrinology Service (Drs McDermott and Hofeldt), Department of Medicine, Fitzsimons Army Medical Center, Aurora, Colo.

Arch Dermatol. 1983;119(12):1019-1021. doi:10.1001/archderm.1983.01650360065016

Neurofibromatosis (Recklinghausen's disease) is a well-recognized syndrome transmitted by an autosomal dominant gene. The cutaneous and internal manifestations of the disease have been well known for almost 100 years, but little is known about its pathogenesis. Eruptive neurofibromatosis has previously been reported in association with puberty and pregnancy, suggesting that hormones or growth factors may modulate tumor growth.1,2 We report herein the development of eruptive neurofibromatosis in association with anorexia nervosa.

Report of a Case  An 18-year-old woman with known neurofibromatosis and anorexia nervosa was seen in April 1981 with a two- to three-week history of the appearance of several hundred papules on her trunk and extremities. She had been previously diagnosed as having neurofibromatosis at 2 years of age, based on the presence of multiple café au lait spots on the trunk and extremities, defective development of the orbital bones, and neurofibromas of the neck and right foot.