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December 1983

Monozygotic Twins Discordant for Cutaneous Mastocytosis

Author Affiliations

From the Dermatology Clinic, University of Milan (Italy), and the Division of Dermatology, Ospedali Riuniti di Bergamo (Italy) (Drs Cainelli, Marchesi, and Rozzoni); and the Institute of General Biology and Medical Genetics, University of Pavia (Italy) (Dr Pasquali).

Arch Dermatol. 1983;119(12):1021-1022. doi:10.1001/archderm.1983.01650360067017

Cutaneous mastocytosis (CM) may be transmitted as an autosomal dominant trait.1 In 1938, Dommartin2 published a thesis on CM in twins in which he reviewed previous cases of monozygotic twins who were concordant for the disease. Then, he described one case in which only one of a pair of dizygotic twins was affected.

In all of the literature we found descriptions of two pairs of dizygotic twins discordant for CM, eight pairs for monozygotic twins both of whom had the disease,3,4 and three pairs of monozygotic twins discordant for the disease.3 Moreover, a set of monozygotic triplets, all of whom were affected with CM, has been described.5 We report a fourth instance of discordance for CM in monozygotic twins and review some possible explanations for this occurrence.

Report of a Case  Four-year-old male twins were seen because of fixed skin lesions, present in one boy,

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