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January 1984

Cutaneous Periarteritis Nodosa: Hepatitis B Surface Antigen-Containing Immunocomplexes and Polymorphonuclear-Leukocyte Lysosomal Enzyme Release

Author Affiliations

From the Departments of Hematology (Dr Van de Pette), Oral Immunology and Microbiology (Ms Jarvis and Dr Wilton), and Dermatology (Dr MacDonald), Guy's Hospital, London.

Arch Dermatol. 1984;120(1):109-111. doi:10.1001/archderm.1984.01650370115024

• In a patient with cold-induced cutaneous periarteritis nodosa, cryoprecipitation of a circulating hepatitis B surface antigen-containing immunocomplex resulted in phagocytosis by neutrophils and monocytes with prominent vacuolation of the cells and extracellular release of lysosoma enzymes. We believe this immunocomplex attached itself to the cell membrane and induced vacuolation and degranulation in normal neutrophils.

(Arch Dermatol 1984;120:109-111)