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January 1984

Response of Transient Acantholytic Dermatosis to Photochemotherapy

Author Affiliations

From the Department of Dermatology, Beth Israel Hospital and Harvard Medical School, The Charles A. Dana Biomedical Research Institute and the Harvard-Thorndike Laboratory of the Beth Israel Hospital, Boston.

Arch Dermatol. 1984;120(1):121-122. doi:10.1001/archderm.1984.01650370127026

Transient acantholytic dermatosis (TAD) is a cutaneous disorder of unknown cause characterized by pruritic, discrete papules and papulovesicles. The lesions are usually located on the trunk. Men over the age of 40 years are predominantly affected. Since the time of Grover's1 initial report, which described six patients whose conditions cleared spontaneously within weeks to months, it has been repeatedly recognized that this entity need not be transient and may in fact persist for years.2-5 Although treatment with topical and systemic adrenal steroids or high doses of oral vitamin A is sometimes of value,5 these therapies are most often unsatisfactory. We describe a patient with persistent TAD who responded to psoralens and UV-A (PUVA) therapy and in whom a shielded control patch remained involved with the disease.

Report of a Case  A 59-year-old man was seen in December 1980, for a widespread pruritic eruption of five months' duration.