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February 1984

Factor VIII-Related Antigen in Kaposi's Sarcoma in Young Homosexual Men

Author Affiliations

From the Departments of Pathology (Dr Flotte), Dermatology (Drs Hatcher and Friedman-Kien), and Microbiology (Dr Friedman-Kien), New York University School of Medicine, New York. Dr Flotte is now at the Massachusetts General Hospital, Boston.

Arch Dermatol. 1984;120(2):180-182. doi:10.1001/archderm.1984.01650380040007

• This study investigated the histogenesis of the Kaposi's sarcomas occurring in young homosexual men. Paraffin sections of seven tumors were stained for factor VIII-related antigen by the unlabeled peroxidase antiperoxidase method. Both the spindle cell component and the cells lining vascular channels contained factor VIII-related antigen, a marker for endothelial cells. Our study supports the hypothesis that both components of Kaposi's sarcoma are of endothelial cell origin.

(Arch Dermatol 1984;120:180-182)