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February 1984

1% Sulconazole Cream v 2% Miconazole Cream in the Treatment of Tinea Versicolor: A Double-blind, Multicenter Study

Author Affiliations

From the Institute of Clinical Medicine (Drs Tanenbaum and Akers and Ms Anderson), and the Department of Biostatistics (Dr Rosenberg), Syntex Research, Palo Alto, Calif.

Arch Dermatol. 1984;120(2):216-219. doi:10.1001/archderm.1984.01650380076015

• Sulconazole nitrate, a new imidazole derivative, was formulated at 1% concentration in a cream vehicle and compared with 2% miconazole nitrate cream in the treatment of tinea versicolor in a double-blind, multicenter, randomized, parallel clinical trial. At baseline, all of the 192 patients enrolled had a positive potassium hydroxide (KOH) preparation; itching was reported by 48% of the patients. The medications were applied twice daily for three weeks. Of 181 patients analyzed for efficacy at the end of the treatment trial, 93% of sulconazole-treated patients and 87% of miconazole-treated patients had become KOH negative. The complete clearing of tinea versicolor lesions occurred in 89% of sulconazole-treated patients and 82% of miconazole-treated patients. Both drugs were well tolerated with no systemic reactions reported. Drug-related adverse cutaneous reactions, predominantly transient itching, were reported in eight patients receiving sulconazole and in four patients receiving miconazole.

(Arch Dermatol 1984;120:216-219)

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