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March 1984

Association of Juvenile Xanthogranuloma With Juvenile Myeloid Leukemia

Author Affiliations

From the Departments of Pathology (Drs Cooper and Frierson), Dermatology (Drs Cooper and Kayne), and Pediatrics (Dr Sabio), University of Virginia, Charlottesville.

Arch Dermatol. 1984;120(3):371-375. doi:10.1001/archderm.1984.01650390093020

• Multiple cutaneous xanthomas developed in a patient at the age of 10 months, and juvenile chronic myeloid leukemia (JCML) developed at the age of 30 months. The xanthomas were histopathologically consistent with a diagnosis of juvenile xanthogranuloma (JXG). A review of other cases of JCML with JXG indicates that the cutaneous lesions have many clinical and histopathologic similarities to sporadic JXG but are more often multiple or papular and confluent. In addition to JXG, a few children with JCML also have multiple café-au-lait spots and a family history of neurofibromatosis.

(Arch Dermatol 1984;120:371-375)

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