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March 1984

Transepithelial Elimination in Chromomycosis

Arch Dermatol. 1984;120(3):400-401. doi:10.1001/archderm.1984.01650390122029

Since its description by Mehregan et al1 in 1967, transepithelial elimination (TE) has been widely recognized as a histopathologic phenomenon in the removal of foreign material or altered tissue components from the skin. We recently observed TE in a patient suffering from chromomycosis. To our knowledge, this is only the second such case reported.

Report of a Case  A 53-year-old man was seen because of a slowly growing 5 × 8-cm verrucous plaque on the dorsolateral aspect of his left foot involving the fourth and fifth digit. The lesion had been diagnosed as chromomycosis clinically and histologically, and was mycologically confirmed as being caused by Phialophora pedrosoi. Histologic examination disclosed irregular acanthosis with focal areas of pseudoepitheliomatous hyperplasia and overlying hyperparakeratosis. The dermis was filled with a more or less dense inflammation infiltrate composed predominantly of plasma cells (60%), with admixtures of lymphocytes, histiocytes, eosinophils, and multinucleated giant cells.