We describe a patient with leiomyosarcoma of the small intestine in whom the development of a Sister Mary Joseph nodule of the umbilicus was the primary evidence of advancing disease. The appearance of a metastatic umbilical nodule is recognized as a sign of poor prognosis; our patient died within two years after the onset of this lesion.
Powell FC, Cooper AJ, Massa MC, Goellner JR, Su WPD. Leiomyosarcoma of the Small Intestine Metastatic to the Umbilicus. Arch Dermatol. 1984;120(3):402–403. doi:10.1001/archderm.1984.01650390124031
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