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April 1984

Furunculosis and Hidradenitis Suppurativa Response

Author Affiliations

Department of Dermatology West Virginia University Medical Center Morgantown, WV 26506

Arch Dermatol. 1984;120(4):437. doi:10.1001/archderm.1984.01650400019004

To the Editor.—  We wish to communicate briefly the results of an open clinical trial, performed with informed consent, using tolmetin sodium to treat chonic furunculosis and hidradenitis suppurativa.Four patients, ages 4 to 30 years, had histories of furunculosis of several years' duration with minimal response to repeated courses of various antibiotics. All patients experienced nearly complete clearing of their lesions within days to weeks after the institution of tolmetin sodium therapy. Their furunculosis flared up after cessation of treatment, but cleared again after the tolmetin sodium therapy was resumed. Subsequently, the patients were treated with gradually decreasing dosages during a period of months and the furunculosis did not flare up after treatment was discontinued. All patients have remained nearly lesion-free for periods of up to one year after stopping treatment.Two patients with long-standing hidradenitis suppurativa, aged 24 and 26 years, were similarly treated. Both demonstrated notable improvement