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May 1984

Dermal Lipofuscinosis Associated With Amiodarone Therapy: Report of a Case

Author Affiliations

From the Departments of Dermatology (Dr Miller) and Pathology (Dr McDonald), Victoria General Hospital and Dalhousie University, Halifax, Nova Scotia, Canada.

Arch Dermatol. 1984;120(5):646-649. doi:10.1001/archderm.1984.01650410088022

• Amiodarone hydrochloride is a noncompetitive adrenergic blocker used in the treatment of tachyarrhythmias. Its use in Europe and South America has been associated with cutaneous pigmentation thought to be caused by lipofuscin deposition in the dermis. We describe a similar case occurring in North America. A skin biopsy specimen from the patient was examined by light microscopy, fluoresence microscopy, and electron microscopy. From these examinations, a diagnosis of dermal lipofuscinosis was made.

(Arch Dermatol 1984;120:646-649)

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