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May 1984

Transepithelial Elimination of Amyloid

Arch Dermatol. 1984;120(5):679-680. doi:10.1001/archderm.1984.01650410123029

Transepithelial elimination (TE), a dermatologic process first described in detail by Mehregan1 in 1968, is being reported with increasing frequency. We recently encountered a case of cutaneous macular amyloidosis that histologically exhibited the features of TE.

Amyloidosis associated with TE was first recorded by Freudenthal2 in 1930 and later by Anekoji3 in 1961. To our knowledge, no subsequent cases involving amyloid and TE have been reported.

Report of a Case  A 48-year-old man was seen because of a hyperpigmented, slightly pruritic rash of ten years' duration on his back. Physical examination revealed brown and gray papules on the back. In some areas, the papules were confluent, forming a pebble-grain appearance.