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June 1984

Dominant Dystrophic Epidermolysis Bullosa

Author Affiliations

The Skin Hospital Quay Street Manchester M3 3HL, England

Arch Dermatol. 1984;120(6):707-708. doi:10.1001/archderm.1984.01650420017004

To the Editor.—  In the July Archives Zackheim reported1 that human growth hormone failed to influence the course of dominant dystrophic epidermolysis bullosa (DDEB) in two children given eight-week courses of human growth hormone injections. We similarly failed to demonstrate any beneficial effect from a six-month course of human growth hormone injections given to an adult with DDEB.

Report of a Case.—  A 47-year-old woman had suffered from recurrent blistering and scarring of the skin since infancy. Her father and her son were similarly affected. Examination showed atrophy and scarring, mostly affecting the extensor aspects of the arms, the dorsa of the hands and the fingers, with loss of several fingernails. There were variably sized hemorrhagic bullae, erosions, and crusts within the scarred areas. Similar but less severe changes were present on the lower limbs, especially around the knees and on the fronts of the shins. There was no

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