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June 1984

Penicillamine-Induced Pemphigus: Immunoglobulin From This Patient Induces Plasminogen Activator Synthesis by Human Epidermal Cells in Culture: Mechanism for Acantholysis in Pemphigus

Author Affiliations

From the Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham, NC. Dr Hashimoto is now with Osaka (Japan) University School of Medicine, and Dr Lazarus is now with the University of Pennsylvania School of Medicine, Philadelphia.

Arch Dermatol. 1984;120(6):762-764. doi:10.1001/archderm.1984.01650420072019

• The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation.

(Arch Dermatol 1984;120:762-764)

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