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June 1984

Antimalarial Psychosis Revisited

Author Affiliations

From the Western Missouri Mental Health Center, Kansas City (Drs Khalid and Kinney), and the University of Missouri-Kansas City Schools of Pharmacy and Medicine (Dr Evans). Dr Kinney is now with the School of Pharmacy, Tucson.

Arch Dermatol. 1984;120(6):765-767. doi:10.1001/archderm.1984.01650420075020

• Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus. After two weeks of drug treatment, the patient exhibited symptoms similar to those seen in the manic phase of bipolar affective disorder. Although the incidence of antimalarial psychosis is unclear and perhaps small, we recommend close observation of patients for behavioral changes suggesting the development of antimalarial psychosis. Astute observation, leading to the early detection of behavioral changes, may help avert the development of a costly and disabling complication of drug therapy.

(Arch Dermatol 1984;120:765-767)

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