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June 1984

DR Antigens in Bullous Pemphigoid

Arch Dermatol. 1984;120(6):795. doi:10.1001/archderm.1984.01650420105026

Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the in vivo deposition of IgG and/or complement at the basement membrane zone (BMZ) and by the presence of anti-BMZ antibody in the serum.1 Earlier studies have demonstrated that there is no increased incidence of a specific HLA antigen of the A or B locus in white American or Japanese patients.2,3 Recent evidence suggests that the linkage between HLA and disease association is stronger with antigens of the D locus.4 In certain diseases, eg, rheumatoid arthritis and Goodpasture's syndrome, in which there are no known associations with HLA-A, B, or C locus antigens, now there are significant associations with the D locus antigens.4

In this study, HLA antigens of the A, B, C, and D loci were tested in 42 patients with BP to determine any linkage with the immune response genes. No linkage was