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June 1984

DR Antigens in Bullous Pemphigoid

Author Affiliations

From the Division of Dermatology, Department of Medicine (Drs Ahmed and Konqui) and the Tissue Typing Laboratory, Department of Surgery (Drs Park, Tiwari, and Terasaki), UCLA School of Medicine, Los Angeles.

Arch Dermatol. 1984;120(6):795. doi:10.1001/archderm.1984.01650420105026

Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the in vivo deposition of IgG and/or complement at the basement membrane zone (BMZ) and by the presence of anti-BMZ antibody in the serum.1 Earlier studies have demonstrated that there is no increased incidence of a specific HLA antigen of the A or B locus in white American or Japanese patients.2,3 Recent evidence suggests that the linkage between HLA and disease association is stronger with antigens of the D locus.4 In certain diseases, eg, rheumatoid arthritis and Goodpasture's syndrome, in which there are no known associations with HLA-A, B, or C locus antigens, now there are significant associations with the D locus antigens.4

In this study, HLA antigens of the A, B, C, and D loci were tested in 42 patients with BP to determine any linkage with the immune response genes. No linkage was

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