To the Editor.—
Injectable collagen has been used in California for approximately five years and, in 1981, gained Food and Drug Administration approval to be used nationally.Collagen implant (Zyderm), a highly purified bovine dermal collagen, contains a small amount of xylocaine and has been used for the augmentation of certain dermal defects. Depressed surgical scars, acne pits and scars, atrophy, and aging lines have been treated in a "building-up" procedure. Several thousand patients have been treated to date. It was shown not to be an allergen in animal work. A few reported instances of localized erythema, localized swelling, and localized induration have been noted. At times, sunlight exposure or alcoholic intake were thought to be a causative factor. Test doses in the forearm are recommended before treatment. Occasional reports of urticarial reactions and other generalized
Rapaport MJ. Granuloma Annulare Caused by Injectable Collagen. Arch Dermatol. 1984;120(7):837–838. doi:10.1001/archderm.1984.01650430023004
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