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July 1984

Human Absorption of Crude Coal Tar Products

Author Affiliations

From the Department of Dermatology, Tulane School of Medicine, New Orleans (Drs Storer and Millikan and Mr Griffing), the Center for Bio-Organic Studies, University of New Orleans, Lakefront (Mr DeLeon and Dr Laseter).

Arch Dermatol. 1984;120(7):874-877. doi:10.1001/archderm.1984.01650430060011

• Five normal adult volunteers without cutaneous disease applied 2% crude coal tar to the skin for eight-hour periods on two consecutive days. Blood extracts subjected to gas chromatography and mass spectrometry yielded evidence of absorption in all five volunteers. Phenanthrene, anthracene, pyrene, and fluoranthene, found in four of our volunteers, have been shown to be tumor initiators or cocarcinogens.

(Arch Dermatol 1984;120:874-877)

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