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July 1984

Progressive Cutaneous Herpes Simplex Infection in Acute Myeloblastic Leukemia: Successful Treatment With Interferon and Cytarabine

Author Affiliations

From the Departments of Medicine (Drs Shalev, Green, and Bentwich), and Pathology (Dr Hurwitz), the Hematology (Dr Berrebi) and Dermatology (Dr Frumkin) Units, and the Pediatric Research Laboratories (Dr Levin), Kaplan Hospital, Rehovot, Israel. Affiliated with the Medical School of the Hebrew University and Hadassah, Jerusalem.

Arch Dermatol. 1984;120(7):922-926. doi:10.1001/archderm.1984.01650430108020

† A patient had acute myeloblastic leukemia and extensive progressive cutaneous herpes simplex virus infection. Complete and rapid healing of skin lesions with remission of the leukemia occurred during 15 days of therapy with human leukocyte interferon and minimal doses of cytarabine hydrochloride. Pharmacokinetic studies showed that the patient had a defective antiviral interferon response, which was effectively corrected by treatment with interferon alpha. This may help to explain the dramatic response of both conditions to therapy.

(Arch Dermatol 1984;120:922-926)

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