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July 1984

Nail Dystrophy Following Intralesional Injections of Bleomycin for a Periungual Wart

Author Affiliations

From the Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Arch Dermatol. 1984;120(7):963-964. doi:10.1001/archderm.1984.01650430153030

The successful treatment of periungual warts is often difficult to achieve. Numerous treatments have been advocated, but therapy is hindered by the ease with which it induces pain in these locations and the tendency of the lesions to involve subungual tissue. One recently introduced mode of therapy for such warts is intralesional administration of bleomycin sulfate (Verrublen).

A patient with a periungual wart lost his fingernail following intralesional bleomycin therapy, followed by regrowth of a dystrophic nail. This abnormal nail growth pattern has persisted for two years following therapy.

Report of a Case  A 42-year-old man was seen on May 10, 1982, for a periungual wart that had been present on the distal phalanx of the right middle finger since 1975. The wart had been cauterized twice in February and September of 1977 with subsequent recurrence. The patient was then referred to the Department of Radiotherapy, and he received one

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