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August 1984

Colchicine Therapy in Recurrent Oral Ulcers

Author Affiliations

Ear, Nose, and Throat Department Soroka Medical Center PO Box 151 Beer-Sheva 84101, Israel

Arch Dermatol. 1984;120(8):994. doi:10.1001/archderm.1984.01650440024010

To the Editor.—  During the past two decades, colchicine has been shown to be effective in treating a wide variety of inflammatory disorders, including the cutaneous lesions of Behçet's disease.1 As there is no clear-cut distinction between recurrent oral ulcers or so-called aphthous stomatitis and the mucosal involvement in Behçet's disease,2 we used colchicine therapy in four cases of protracted aphthous stomatitis.

Report of Cases.—Case 1.—  A 32-year-old woman had a long history of recurrent ulceration of the mouth during every menstrual period. Following a prodromal phase of soreness and burning sensation for one to two days, two or three small aphthous ulcers appeared, causing pain for ten days. Oral colchicine, 0.6 mg/day, was administered for a month, with no recurrence of the ulcers during the subsequent menstrual period. However, the patient complained of nausea after one month of therapy, so we limited administration of the