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September 1984

Contact Sensitization in Patients With Vitiligo and in Vitiliginous Skin

Author Affiliations

Clinique Dermatologique 1, Place de l'Hôpital 67091 Strasbourg, France

Arch Dermatol. 1984;120(9):1139. doi:10.1001/archderm.1984.01650450021006

To the Editor.—  We were interested in the article by Uehara et al1 on diminished contact sensitivity response in vitiliginous skin. We had the same experiences in treating 18 cases of vitiligo2: the sensitization to dinitrochlorobenzene (DNCB) was elicited, according to the method of Bleumink et al,3 in the normal skin of nine patients (group A) and in the vitiliginous skin of nine patients (group B). In each patient the challenge tests were performed both in normal and achromic skin with three different dilutions of DNCB (0.3%, 0.1%, and 0.03%; 30,10, and 3 μg). Sensitization was obtained in all the patients and we did not observe a substantial difference in the reactivity between normal and vitiliginous skin areas. However, the mean level of cutaneous sensitization was lower when the elicitation occurred through achromic skin (group B): the difference was chiefly noticeable with the lowest DNCB dose used

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