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September 1984

Psoralens and UV-A and UV-B Twice Weekly for the Treatment of Psoriasis

Author Affiliations

From the Departments of Dermatology, Harvard Medical School, Massachusetts General Hospital (Drs Diette, Momtaz-T, and Parrish), and Beth Israel Hospital (Drs Diette, Stern, and Arndt), Boston.

Arch Dermatol. 1984;120(9):1169-1173. doi:10.1001/archderm.1984.01650450051017

• In an effort to determine if combination phototherapy (psoralens and UV-A [PUVA]) [PUVA-UV-B]) administered twice weekly provides a substantial advantage over therapy with PUVA alone, we investigated twice-weekly PUVA-UV-B therapy for the treatment of psoriasis. In a bilateral comparison study of 11 patients, we found that seven cases of psoriasis cleared in the same number of treatments with PUVA-UV-B or PUVA, but in four cases the PUVA-UV-B treated side cleared significantly more rapidly. In a study of these 11 split cases, plus ten additional patients treated with PUVA-UV-B twice weekly, this therapy was effective in clearing psoriasis. A bilateral comparison of "aggressive" and "nonaggressive" PUVA and UV-B increments in ten patients suggested that lower doses of PUVA and UV-B may, in the majority of patients, be equally effective. Further study is necessary to define the maximally effective protocol — maximizing clearance yet minimizing UV exposure, acuteside effects, and long-term toxic reactions.

(Arch Dermatol 1984;120:1169-1173)

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