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September 1984

Confluent and Reticulated Papillomatosis Successfully Treated With the Aromatic Etretinate

Author Affiliations

From the Department of Dermatology, University Hospital of Utrecht, Catharijnesingel, the Netherlands.

Arch Dermatol. 1984;120(9):1236-1237. doi:10.1001/archderm.1984.01650450118033

Gougerot and Carteaud1 were the first authors to describe confluent and reticulated papillomatosis. Since then (1932) there has been considerable controversy over whether it is a distinct disease. Currently, however, it is accepted as such.2

The cause of the disorder is undetermined. Endocrinologic disturbances, an abnormal host reaction to Pityrosporon orbiculare, a variant of amyloidosis cutis,3 a genetically determined defect of keratinization,4 or a more general hereditary predisposition5 have all been implicated as possible pathogenetic factors.

Ichthyosis, erythrokeratodermia figurata variabilis, acanthosis nigricans of all types,2 tinea versicolor, and pityriasis rubra pilaris should be considered in the differential diagnosis.

Patients with confluent and reticulated papillomatosis do not respond well to treatment. We describe a patient successfully treated with the aromatic retinoid etretinate (Tigason).

Report of a Case  A 25-year-old man, suffering from a mild pruritic eruption, was seen in our outpatient clinic. The eruption had begun

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