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September 1984

Autoimmunity in Psoriasis

Author Affiliations

Santa Barbara, Calif


edited by Ernst H. Beutner, 313 pp, with illus, $79.50, Boca Raton, Fla, CRC Press Inc, 1982.

Arch Dermatol. 1984;120(9):1247. doi:10.1001/archderm.1984.01650450129045

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Autoimmunity in Psoriasis is a monograph featuring the contributions of 34 international experts in the field. The book is divided into sections dealing with general concepts of autoimmunity, the genetics and histology of psoriasis, humoral and cell-mediated immune function in psoriasis, and finally a section with detailed descriptions of some of the key methods used in the experimental studies described in the book.

Beutner's initial chapter provide a framework for addressing the role of autoimmune processes in psoriasis. His unified concept of autoimmunity is an elegant theory relating autoimmune processes in both physiologic and pathologic states: some autoantibodies are naturally occurring and do not seem to be specifically involved in disease processes. The recently discovered antibodies to the 0-adrenergic receptor would seem to be an example of a physiologic antibody found in normal subjects, as well as atopic persons, and its relevance to disease, if any, is not clear. Pathologic

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