This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
We appreciate the thoughtful comments from Drs Wolf and Livni. We totally agree with them that it is possible to demonstrate delayed hypersensitivity even in cases with clinical manifestation of immediate hypersensitivity type and that such positive test results may not mean a direct role of cellular immunity in the pathogenesis of the disease. However, we do not think that we need not to pay any attention to the importance of the demonstrability of a delayed hypersensitivity reaction to a causative drug in a case of a drug eruption, such as TEN. We think that nobody would deny the possibility that a kind of hypersensitivity reaction plays an important role, particularly when the site of the positive patch test reaction showed remarkable degenerative changes of the epidermis as compared with those found in ordinary allergic contact dermatitis (as in our case). Thus we suspected a possibility that an
Tagami H. Delayed Hypersensitivity in Drug-Induced Toxic Epidermal Necrolysis (TEN)-Reply. Arch Dermatol. 1984;120(12):1555. doi:10.1001/archderm.1984.01650480017003
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: