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December 1984

Hyperbaric Oxygen Techniques-Reply

Author Affiliations

Division of Dermatology UCLA-San Fernando Valley Program Veterans Administration Medical Center 16111 Plummer Street Sepulveda, CA 91343

Arch Dermatol. 1984;120(12):1557. doi:10.1001/archderm.1984.01650480018007

In Reply.—  We are grateful to Dr Zanetti for his illuminating comments. We admit that 30 mm Hg above the ambient atmospheric pressure does not sound impressive. Nevertheless, the application of oxygen at this mildly hyperbaric level has been shown to result in the production of granulation tissue clinically, and in marked vascular and endothelial proliferation seen both on light microscopy and electron microscopy (unpublished data, M.C.Y.H., February 1984). In fact, in biopsy specimens from the newly formed granulation tissue taken some weeks after the initiation of hyperbaric oxygen, we have observed that the endothelial cells showed evidence of oxygen toxicity in the form of irregular and serrated nuclear outlines, even at these "low" oxygen pressures (unpublished data, M.C.Y.H., February 1984). These recent findings, therefore, support our clinical observations that interrupted therapy produced better results than continuous hyperbaric oxygen therapy.We agree with Dr Zanetti's point that when pressure is

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