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December 1984

Response of Mycosis Fungoides to Topical Chemotherapy With Mechlorethamine

Author Affiliations

From the Lymphoma Section, Department of Dermatology (Drs Ramsay and Parnes), and the Biostatistics and Epidemiology Laboratory, Department of Environmental Medicine (Dr Dubin), New York University Medical Center.

Arch Dermatol. 1984;120(12):1585-1590. doi:10.1001/archderm.1984.01650480047016

• Seventy-six patients with mycosis fungoides (MF) were given topical mechlorethamine hydrochloride therapy. Allergic contact hypersensitivity reactions to the drug developed in 51 patients (67.1%). Sixty-four patients of the original 76 continued therapy, with 43 (67.2%) achieving a complete remission and 12 (18.8%) achieving a partial remission. Stage I disease responded significantly better than did subsequent, more severe disease stages. The median times to complete remission were 5.6 months, 32.3 months, and 22.3 months for stage I, II, and III disease, respectively. The conditions of patients with contact sensitivity did not respond better than those of patients without contact sensitivity. Patients with substage A disease did not respond better than patients with substage B disease. These findings are encouraging and indicate that the use of topically applied mechlorethamine for early-stage MF should be continued, despite the development of contact dermatitis to the drug.

(Arch Dermatol 1984;120:1585-1590)

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