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January 1985

Systemic Lupus Erythematosus With Pemphigus Vulgaris

Author Affiliations

University Department of Medicine Singapore General Hospital Singapore 0316

Arch Dermatol. 1985;121(1):26-27. doi:10.1001/archderm.1985.01660010030014

To the Editor.—  Systemic lupus erythematosus (SLE) is a collagen vascular disease with multisystem involvement, including often the integument. Pemphigus is a group of bullous diseases affecting the skin and mucous membranes.1 Although both conditions are generally believed to be part of the autoimmune spectrum, each have distinctive clinical and immunopathologic characteristics. Pemphigus is also an organ-specific autoimmune disease with antibodies targeted only on the skin and mucous membranes with stratified epithelia, whereas SLE is non-organ specific autoimmune disease with several types of antinuclear antibodies (ANA) affecting many organs. We describe herein a patient with definite evidence of SLE in whom typical features of pemphigus vulgaris developed four months later, while the patient was receiving corticosteroid therapy.

Report of a Case.—  A 59-year-old Chinese woman was seen at the Singapore General Hospital in July 1982, because of a sixmonth history of polyarthritis involving the knees, elbows, wrists, and fingers.

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