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March 1985

The Mutagenicity of Dinitrochlorobenzene

Author Affiliations

From the Photobiology Laboratory, Veterans Administration Medical Center (Dr Black and Ms Gerguis), and the Department of Dermatology, Baylor College of Medicine (Drs Black and Castrow), Houston.

Arch Dermatol. 1985;121(3):348-349. doi:10.1001/archderm.1985.01660030070021

• A sample of dinitrochlorobenzene, determined by gas-liquid chromatography and mass spectrometry to be greater than 98% pure, was tested in the Salmonella typhimurium plate assay. The chemical evoked a marked mutagenic response at all concentrations tested (3 to 150 μg per plate). These results confute the suitability of this agent for the treatment of benign skin disorders.

(Arch Dermatol 1985;121:348-349)

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