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March 1985

A Histopathologic Evaluation of Nevocellular Nevi in Pregnancy

Author Affiliations

From the Departments of Pathology and Dermatology (Drs Foucar and Bentley) and Obstetrics and Gynecology (Dr Laube), University of Iowa College of Medicine, Iowa City, and the Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis (Dr Rosai). Dr Foucar is now with Presbyterian Hospital, Albuquerque.

Arch Dermatol. 1985;121(3):350-354. doi:10.1001/archderm.1985.01660030072022

• A detailed histopathologic study was performed on 128 nevi removed from 86 pregnant white patients. None of the patients had clinical evidence of the dysplastic nevus syndrome, and none of the excised nevi were clinically suspicious for melanoma. One third of patients reported some change in nevi during pregnancy. Nevi from an age-matched male control population (50 patients) had a spectrum of histologic features essentially identical to the pregnant patients, while nevi from a female control population (51 patients) showed slightly less atypia according to our criteria. The differences found between the nevi from pregnant and control women suggest that a mild degree of histopathologic atypia or "activation" is associated with pregnancy. However, in the population studied, these changes were never of sufficient degree to result in diagnostic confusion.

(Arch Dermatol 1985;121:350-354)