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May 1985

Acanthosis Nigricans

Author Affiliations

Louisiana State University Medical Center 1901 Perdido St New Orleans, LA 70112-1393

Arch Dermatol. 1985;121(5):588. doi:10.1001/archderm.1985.01660050036005

To the Editor.—  In the October 1984 Archives two separate articles appeared describing pseudo1 and familial2 forms of acanthosis nigricans; one of the articles commented on how to differentiate the various types. Another form, which has received little recognition, is that of immunosuppression-induced acanthosis nigricans as originally described by Koranda et al.3 The development of de novo malignant neoplasms is an acknowledged complication of immunosuppression in organ-homograft recipients. In this study, it was noted that 10% of 200 consecutive renal transplant patients were reported to develop cutaneous manifestations of the dermatosis. The ages ranged from 13 to 41 years, with a mean of 27 years (only two patients were obese) and the immunosuppressive regimen usually consisted of azathioprine and predisone with some of the patients receiving antilymphocytic globulin or cyclophosphamide. Although malignant neoplasms have not been found in these patients, this group represents one predisposed to but

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