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June 1985

Immunodiagnosis in Dermatopathology

Author Affiliations

Department of Pathology Brigham and Women's Hospital 75 Francis St Boston, MA 02115

Arch Dermatol. 1985;121(6):731-733. doi:10.1001/archderm.1985.01660060045017

In an editorial that appeared in the Archives over two years ago, Berger and Edelson1 described the clinical utility of monoclonal antibodies that are primarily directed against T-cell differentiation antigens. Since that time, literally thousands of studies have emerged that examine the application of novel polyclonal and monoclonal antibody reagents to practical and research-related settings. The use of immunocytochemistry in the evaluation of biopsy tissue is now an accepted adjunct to tumor diagnosis in many pathology laboratories. In this issue of the Archives, a number of articles underscore our growing dependence on these techniques for understanding pathogenetic mechanisms of inflammatory dermatoses, defining histogenetic relationships in certain cutaneous neoplasms, enhancing diagnostic accuracy and efficiency, and monitoring therapeutic responses.

IMMUNOCYTOCHEMISTRY OF INFLAMMATORY DERMATOSES  The prototype of many cutaneous inflammatory disorders is the delayed hypersensitivity response. In this reaction, antigens, either exogenous or endogenous, are presented by dendritic cells