[Skip to Navigation]
June 1985

Extramammary Paget's Disease of the Perianal and Perineal Regions: Evidence of Apocrine Derivation

Author Affiliations

From the Dermatopathology Unit, Department of Pathology, Brigham and Women's Hospital (Drs Mazoujian, Pinkus, and Murphy), and the Department of Dermatology, Massachusetts General Hospital (Dr Momtaz-T), Harvard Medical School, Boston. Dr Merot is a visiting research fellow from the Clinique de Dermatologie, Hôpital Cantonal Universitaire, Geneva.

Arch Dermatol. 1985;121(6):750-752. doi:10.1001/archderm.1985.01660060064022

• A case of perianal and perineal extramammary Paget's disease in a male is reported. The presence of gross cystic disease fluid protein—a new marker of apocrine epithelia—in Paget's cells provides additional insight into the histopathogenesis of this condition. This marker may be a valuable diagnostic adjunct in evaluating intraepithelial malignancies at a variety of anatomic sites.

(Arch Dermatol 1985;121:750-752)