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July 1985

Eosinophilic Cellulitis (Wells' Syndrome)

Author Affiliations

Department of Pathology; Department of Dermatology Creighton University School of Medicine/Saint Joseph Hospital 601 N 30th St Omaha, NE 68131

Arch Dermatol. 1985;121(7):836. doi:10.1001/archderm.1985.01660070024006

To the Editor.—  In 1971 Wells described an unusual cutaneous eruption resembling acute cellulitis. Grossly it appears as single or multiple erythematous, edematous plaques and histologically demonstrates an intense eosinophilic infiltrate with an edematous dermis, which later is infiltrated by histiocytes. Many patients demonstrate a peripheral blood eosinophilia, and several authors have reported more striking hematologic alterations.

Report of a Case.—  A 36-year-old woman was seen in February 1981 for a cutaneous eruption that had been present since late 1980. The eruption was characterized by arcuate, raised, erythematous lesions on both wrists and thighs. Prior to admission, the patient had received erythromycin and prednisone. Cutaneous biopsy at that time revealed a nonspecific perivascular infiltrate composed of an admixture of lymphocytes with a substantial, but smaller, number of eosinophils. Scattered, small eosinophilic granules were present in an edematous dermis, with focal fragmentation of the collagen fibers.Laboratory studies indicated a hemoglobin

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