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August 1985

Application of Topical Corticosteroids

Arch Dermatol. 1985;121(8):971. doi:10.1001/archderm.1985.01660080025009

To the Editor.—  The application schedule of potent glucocorticosteroids is important for several reasons. These steroids are widely used for treatment of various dermatoses, and potent glucocorticosteroids have adverse side effects, such as atrophy1 and tachyphylaxis.2 Thus, it is important to optimize the application schedule to get maximum clinical effect with minimal side effects.Du Vivier et al3 reported that, in mouse skin, the application of a glucocorticosteroid once every other day resulted in marked suppression of epidermal cell DNA synthesis and that the application of a steroid twice daily was not more effective. Their results suggest that, in clinical practice, one application of a glucocorticosteroid on alternate days is as effective as an application twice a day. We performed a clinical trial in psoriatic patients using both regimens.

Patients and Methods.—  Twenty-nine inpatients with psoriasis were randomly selected for participation in the trial; 28 had psoriasis

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