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August 1985

Dystrophic Epidermolysis BullosaA New Variant Characterized by Progressive Symmetrical Centripetal Involvement With Scarring

Author Affiliations

From the Departments of Dermatology (Drs Fine and Osment) and Medicine (Dr Gay), University of Alabama at Birmingham School of Medicine.

Arch Dermatol. 1985;121(8):1014-1017. doi:10.1001/archderm.1985.01660080068016

• A patient is reported with a form of epidermolysis bullosa, hitherto undescribed to the best of our knowledge, characterized by the slow centripetal progression of symmetrical blister formation, milia, scarring, atrophy, and nail dystrophy. Electron microscopy, immunofluorescence mapping, and KF-1 monoclonal antibody studies confirm this disease to be a form of dystrophic epidermolysis bullosa, probably of autosomal recessive transmission despite the absence of acral deformities, contractures, mucosal involvement, and growth retardation.

(Arch Dermatol 1985;121:1014-1017)