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September 1985

Treatment of Viral Warts With Pressure-Sensitive Adhesive Tape Containing Bleomycin Sulfate

Author Affiliations

Department of Dermatology Hamamatsu University School of Medicine Hamamatsu 431-31 Japan; Nitto Electric Industrial Co, Ltd Ibaraki, Osaka 567 Japan

Arch Dermatol. 1985;121(9):1108. doi:10.1001/archderm.1985.01660090022008

To the Editor.—  The currently employed manipulations for the treatment of common and plantar warts depend mainly on physical and chemical destruction of the warts.1,2 One of the disadvantages in these maneuvers is associated pain at the treated site. Herein, we report the usefulness of pressure-sensitive adhesive tape containing bleomycin sulfate for common and plantar warts.Acrylic adhesive was casted on a nonwoven fabric laminated polyurethane film as a backing. The adhesive surface of the tape was coated evenly with a solution containing bleomycin sulfate (5.3 mg/mL in ethanol and water [9:1]) and dried at room temperature. The final content of bleomycin sulfate was 60 μg/sq cm of the tape, as assessed by high-performance liquid chromatography. Placebo tape did not contain bleomycin sulfate.Seven patients with common warts and two with plantar warts were selected to participate in our study. They had not been treated previously for warts. Bleomycin

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