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September 1985

Lymphomatoid Papulosis Associated With Plaque-Stage and Granulomatous Mycosis Fungoides

Author Affiliations

From the Departments of Dermatology (Drs Kardashian and Zackheim) and Pathology (Dr Egbert), University of California School of Medicine, San Francisco.

Arch Dermatol. 1985;121(9):1175-1180. doi:10.1001/archderm.1985.01660090089020

• A 47-year-old black man had typical papulonodular lesions of lymphomatoid papulosis (LyP) with concurrent plaque-stage mycosis fungoides (MF). Both diagnoses were confirmed histologically. This supports the concept that LyP is part of the spectrum of cutaneous T-cell lymphoproliferative disorders. The patient also had a large nodule and a deeply infiltrated plaque, each of which exhibited a deep granulomatous reaction. These were interpreted as representing granulomatous MF. Clinically, there was an evolution from a predominance of LyP lesions to a predominance of MF plaques. Topical carmustine therapy resulted in a substantial decrease in the number and size of both LyP and MF lesions. Both lesion types involuted with hypopigmentation.

(Arch Dermatol 1985;121:1175-1180)

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