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October 1985

Thrombocytosis in a Patient With Secondary Syphilis

Author Affiliations

Division of Dermatology University of Maryland Hospital 22 S Greene St Baltimore, MD 21201

Arch Dermatol. 1985;121(10):1241-1242. doi:10.1001/archderm.1985.01660100021008

To the Editor.—  Reports of platelet abnormalities accompanying secondary syphilis are uncommon and are largely limited to neonatal patients.1 Although a case of thrombocytosis in congenital syphilis has been published,2 the more common platelet abnormality in this setting is thrombocytopenia.3I describe herein a patient with secondary syphilis, marked thrombocytosis, and evidence of syphilitic hepatitis.

Report of a Case.—  A 33-year-old woman was seen because of a seven-day history of a generalized nonpruritic eruption that had begun on her trunk. On physical examination, she was noted to have a generalized papulosquamous eruption and several erythematous macules bilaterally on the palms and soles. No mucous membrane lesions, lymphadenopathy, or hepatosplenomegaly was present. The patient was afebrile. Her rapid plasma reagent test was reactive to a titer of 1:64, and the FTA-ABS assay was positive. At this time, results of laboratory studies disclosed the following values: white blood cell