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October 1985

Congenital Nevi <10 cm as Precursors to Melanoma: 52 Cases, a Review, and a New Conception

Author Affiliations

From the Department of Clinical and Experimental Dermatology, University of Giessen (Drs Illig and Paul); the Department of Dermatology, University of Erlangen-Nuremberg, Erlangen (Dr Weidner); Tumorklinik Hornheide, University of Münster, Münster-Handorf (Drs Hundeiker and Biess); the Department of Dermatology, University of Cologne (Dr Gartmann); and the Department of Dermatology and Venereology, Medical School of Lübeck (Dr Leyh), West Germany. Dr Weidner is now with the Department of Dermatology, Krankenhaus Bad Cannstatt, Stuttgart, West Germany.

Arch Dermatol. 1985;121(10):1274-1281. doi:10.1001/archderm.1985.01660100054014

• Fifty-two congenital melanocytic nevi (CMN) as precursors to melanoma or severe melanocytic dysplasia were reviewed macroscopically and microscopically. Forty-eight "small" CMN measured less than 10 cm in diameter. Histologically, only five reached to the lower third of the dermis or subcutis ("deep type"); the remaining 47 were limited to the upper two thirds of the corium ("superficial type"). There were 47 invasive melanomas, two in situ melanomas, and three severe focal melanocytic dysplasias. All melanomas were of "epidermal" origin and primarily of the superficial spreading type. The age at diagnosis ranged from 18 to 79 years. Prepubertal melanomas were not observed. Melanoma may also arise on small CMN. The most frequent origin of the melanomas in small CMN and the preferred age at manifestation seem to be different from that for giant nevi.

(Arch Dermatol 1985;121:1274-1281)

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