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October 1985

Cutaneous Xanthomas Associated With Chronic Myelomonocytic Leukemia

Author Affiliations

From the Departments of Medicine, Sections of Dermatology (Dr Vail) and Oncology (Dr Adler), and Pathology (Dr Rothenberg), Morristown (NJ) Memorial Hospital; the Department of Dermatology, University of Medicine and Dentistry of New Jersey, Newark (Dr Vail); and the Departments of Medicine (Dr Adler) and Pathology (Dr Rothenberg), Columbia University College of Physicians and Surgeons, New York.

Arch Dermatol. 1985;121(10):1318-1320. doi:10.1001/archderm.1985.01660100098024

• Monocytic leukemia may be associated with specific cutaneous changes in about a third of all cases, most characteristically the plum-colored nodule. Nonspecific cutaneous xanthomas have occasionally been reported with a variety of leukemias, mostly in the pediatric literature, but the first report (to our knowledge) of acute myelomonocytic leukemia presenting with specific cutaneous xanthomatous lesions appeared in 1982. Herein is reported a case of chronic myelomonocytic leukemia presenting with a papular histiocytic eruption, and later showing striking cutaneous xanthomas, together with autopsy findings. Physicians should be aware of this rare but important association.

(Arch Dermatol 1985;121:1318-1320)