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November 1985

The Clinical Significance of Periodic Acid-Schiff-Positive Deposits in Cuticle-Proximal Nail Fold Biopsy Specimens

Author Affiliations

From the Department of Medicine, Divisions of Dermatology (Drs Scher and Tom) and Rheumatology (Dr Lally), and the Department of Pathology (Dr Bogaars), Brown University School of Medicine, Roger Williams General Hospital, and Providence Veterans Administration Medical Center, Providence, RI.

Arch Dermatol. 1985;121(11):1406-1409. doi:10.1001/archderm.1985.01660110054015

• In vivo capillary microscopic findings and proximal nail fold biopsy specimens from 19 patients with various connective tissue diseases, idiopathic Raynaud's phenomenon, and non-connective tissue diseases were studied. Periodic acid-Schiff-positive serous cuticular deposits were not specific to the group of patients with connective tissue disease. Generally, the severity of deposits correlated with the severity of the in vivo capillary microscopic pattern but not with disease severity or duration. The finding of these cuticular deposits may help to identify those patients with idiopathic Raynaud's phenomenon who are at risk to develop a connective tissue disease.

(Arch Dermatol 1985;121:1406-1409)