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December 1985

Pentoxifylline (Trental) Therapy for Vasculitis of Pityriasis Lichenoides et Varioliformis

Arch Dermatol. 1985;121(12):1487. doi:10.1001/archderm.1985.01660120013010

To the Editor.—  Pentoxifylline (Trental) has been approved by the Food and Drug Administration for the symptomatic treatment of intermittent claudication. This drug lowers blood viscosity and improves erythrocyte flexibility. These effects allow increased blood flow to ischemic tissues.Therapy for pityriasis lichenoides et varioliformis, which is usually not an acute disease, has been somewhat frustrating. The therapy that I have found most useful has been very low-dose methotrexate therapy.1,2 The dosage usually adequate to control the disease is a 2.5-mg tablet taken in the morning and at bedtime over a 12-hour period once a week. Two of my patients have been treated with pentoxifylline.

Report of Cases.—Case 1.—  A 30-year-old woman was first seen on May 8,1985, with a skin problem of 1 ½ years' duration. She had been treated with prednisone and an antibiotic orally with no improvement.Examination revealed 15 red papules, some scaly, on the

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