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January 1986

Quantitative Assessment of Alcohol-Provoked Flushing

Author Affiliations

From the Departments of Pharmacology and Dermatology, Medical College of Virginia and the Dermatology Section, McGuire Veterans Administration Medical Center, Richmond, Va.

Arch Dermatol. 1986;122(1):63-65. doi:10.1001/archderm.1986.01660130067027

• Objective measurements of temperature and blood flow changes by telethermometry and laser Doppler velocimetry (LDV), respectively, were performed continuously in normal subjects after they ingested 0.4 g/kg of ethanol in a volume of 300 mL. Cutaneous temperatures were interpreted by the change in malar thermal circulation index (AMTCI) method. Both the AMTCI method and LDV output correlated significantly with the presence of flushing. The AMTCI method also correlated significantly with LDV output, indicating that the intensity of the flushing reaction can be assessed by both methods. The sensitivity, specificity, and predictive value of a positive result were greater with the LDV method. The time to maximum AMTCI correlated quite closely with the time to maximum LDV output. The results indicate that both LDV and AMTCI methods are valid, noninvasive assays for flushing reactions.

(Arch Dermatol 1986;122:63-65)