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January 1986

Continual Skin Peeling Syndrome: An Electron Microscopic Study

Author Affiliations

From the Dermatology (Drs Silverman and Ellis) and Pathology (Dr Beals) Services, Veterans Administration Medical Center, Ann Arbor, and the Departments of Dermatology (Drs Silverman, Ellis, and Woo) and Pathology (Dr Beals), University of Michigan Medical Center, Ann Arbor. Dr Woo is now in private practice in Calgary, Alberta.

Arch Dermatol. 1986;122(1):71-75. doi:10.1001/archderm.1986.01660130075029

• We encountered a patient with continual skin peeling syndrome, a rare disorder in which generalized, noninflammatory exfoliation of the stratum corneum occurs. Although scaling occurred spontaneously in our patient, he was also able to manually peel sheets of skin without bleeding or pain. Histologically, there was separation of corneocytes above the granular cell layer. Ultrastructural examination revealed an unusual type of intracellular cleavage, in which the plasma membrane of the "peeling" cell remained firmly adherent to the underlying cell while the upper part of the cell exfoliated. Unique intercellular electron-dense globular deposits were localized to the stratum corneum.

(Arch Dermatol 1986;122:71-75)

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