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February 1986

Immunofluorescent Studies of Gastrointestinal Tract Mucosa in Bullous Pemphigoid

Author Affiliations

Department of Dermatology CHU Dupuytren 2 Ave Alexis Carrel 87042 Limoges Cedex, France

Arch Dermatol. 1986;122(2):137-138. doi:10.1001/archderm.1986.01660140021009

To the Editor.—  In a previous report, Binet et al1 described a linear basement membrane zone (BMZ) deposition of IgG and C3 at the periphery of a colonic carcinoma in a patient with bullous pemphigoid (BP). Moreover, we observed esophageal blisters in 4% of patients with typical BP.2 In a prospective study, we attempted to demonstrate the in vivo binding of IgG and/or complement components at the epitheliochorionic junction of the different gastrointestinal (GI) tract mucosa in patients with BP.Endoscopic biopsies were performed on a group of ten consecutive patients with BP (seven women, three men; age range, 50 to 97 years, with a mean age of 74 years) and on a sex- and age-matched, skin disease-free control group (mean age, 70 years; upper GI tract and rectal biopsies were performed on different patients in this group) at various sites (distal esophagus, six patients with BP and