To the Editor.—
In a previous report, Binet et al1 described a linear basement membrane zone (BMZ) deposition of IgG and C3 at the periphery of a colonic carcinoma in a patient with bullous pemphigoid (BP). Moreover, we observed esophageal blisters in 4% of patients with typical BP.2 In a prospective study, we attempted to demonstrate the in vivo binding of IgG and/or complement components at the epitheliochorionic junction of the different gastrointestinal (GI) tract mucosa in patients with BP.Endoscopic biopsies were performed on a group of ten consecutive patients with BP (seven women, three men; age range, 50 to 97 years, with a mean age of 74 years) and on a sex- and age-matched, skin disease-free control group (mean age, 70 years; upper GI tract and rectal biopsies were performed on different patients in this group) at various sites (distal esophagus, six patients with BP and
Bernard P, Souyri N, Pillegand B, Bonnetblanc J. Immunofluorescent Studies of Gastrointestinal Tract Mucosa in Bullous Pemphigoid. Arch Dermatol. 1986;122(2):137–138. doi:10.1001/archderm.1986.01660140021009
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