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February 1986

The Adherence of Staphylococcus aureus to Human Corneocytes

Author Affiliations

From the Dermatology Service, Veterans Administration Medical Center, Long Beach, Calif, and the Department of Dermatology, University of California, Irvine.

Arch Dermatol. 1986;122(2):166-169. doi:10.1001/archderm.1986.01660140056017

Staphylococcus aureus has a peculiar ability to colonize the skin of patients with atopic dermatitis. We examined the possibility that this might be due to a specific ability of this pathogenic staphylococcus to adhere to atopic stratum corneum. We used an in vitro model to show that S aureus does have an unusual ability to adhere to atopic corneocytes when compared with corneocytes obtained from patients with other cutaneous diseases, including psoriasis. Protein A—a component of the staphylococcal cell wall—may be responsible in part for this adherence phenomenon. This trait did not extend to the other gram-positive bacteria tested.

(Arch Dermatol 1986;122:166-169)